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Nicotinamide Improves Skin Photoaging in Mice by Delaying Cellular Senescence and Suppressing the

Xin-Yue Tang1, Ke-Jin Lu1,2, Rui Zhu1

  • 1State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, School of Life Sciences, Southwest United Graduate School, Yunnan University, Kunming 650500, China.

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
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Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...