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Blood-Based Biomarkers for Post-Stroke Cognitive Impairment
Jie Pu1, Wang Guo1, Hongxin Li1
1Graduate School of Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Current Issues in Molecular Biology
|July 28, 2026
Summary
Post-stroke cognitive impairment (PSCI) is rising. This review explores blood biomarkers for identifying PSCI, offering insights for clinical diagnosis and therapy.
Area of Science:
- Neurology
- Biomarker Research
Background:
- Stroke is a leading cause of death and disability.
- Post-stroke cognitive impairment (PSCI) incidence is increasing, affecting memory, attention, and executive functions.
- Current diagnostic tools like MRI and cognitive scales have limitations, and cerebrospinal fluid collection is complex.
Purpose of the Study:
- To review research progress on blood-based biomarkers for PSCI.
- To explore the significance of these biomarkers in disease identification.
- To provide insights for clinical diagnosis and therapy of PSCI.
Main Methods:
- Literature review focusing on blood-based biomarkers in PSCI.
- Analysis of current research on biomarker involvement in PSCI onset and progression.
- Evaluation of advancements in bioassay techniques and equipment.
Main Results:
- Growing evidence supports the role of blood-based biomarkers in PSCI pathogenesis and progression.
- Optimized bioassay techniques enhance the feasibility of using blood biomarkers.
- Blood biomarkers show potential for disease identification and monitoring.
Conclusions:
- Blood-based biomarkers are crucial for understanding PSCI.
- They offer a promising avenue for improved clinical diagnosis and therapeutic strategies.
- Further research into blood biomarkers can significantly advance PSCI management.
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