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Updated: Aug 5, 2026
03:45
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Geographical and Ethnic Heterogeneity in Genetic Dilated Cardiomyopathies
Matilde Di Peppo1, Giovanni Biancofiore1, Andrea Francesca Crudo1
1School of Cardiovascular Diseases, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
International Journal of Molecular Sciences
|July 28, 2026
Summary
Genetic and geographical factors create significant heterogeneity in dilated cardiomyopathy (DCM). Understanding these differences is key to developing tailored diagnostic and therapeutic strategies for DCM patients globally.
Area of Science:
- Cardiology
- Genetics
- Population Health
Background:
- Dilated cardiomyopathy (DCM) is a prevalent global heart condition.
- Advances in genetic research have identified numerous DCM-associated variants.
- Significant global disparities exist in DCM's genetic, geographical, and ethnic landscape.
Purpose of the Study:
- To systematically review and analyze the genetic, geographical, and ethnic heterogeneity of DCM.
- To identify disparities in clinical and instrumental evaluations across diverse populations.
- To propose an integrated model for DCM management considering regional characteristics.
Main Methods:
- Systematic review of existing data on DCM.
- Analysis of genetic variant distribution.
- Evaluation of clinical and instrumental assessment variations.
Main Results:
- DCM exhibits considerable genetic, geographical, and ethnic heterogeneity worldwide.
- Disparities in clinical and instrumental evaluations are evident across populations.
- Variability in clinical and molecular presentation necessitates tailored approaches.
Conclusions:
- A unified operational model integrating diagnostics, imaging, and clinical capabilities is needed for DCM.
- This model should account for regional specificities, migration, and sex differences.
- Characterizing specific genotypes can enable targeted therapies and advance DCM care.
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