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Updated: Aug 5, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Targeting the Epigenome in Colorectal Cancer

Antonios N Gargalionis1, Kostas A Papavassiliou2, Athanasios G Papavassiliou1

  • 1Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

International Journal of Molecular Sciences
|July 28, 2026
PubMed

Insights

Epigenetic alterations drive colorectal cancer (CRC) progression and treatment resistance. Combining epigenetic drugs with other therapies like immunotherapy may improve clinical efficacy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Epigenetic alterations are key drivers in colorectal cancer (CRC) development, contributing to tumor plasticity and resistance to therapies.
  • Current drugs targeting epigenetic modifiers show limited clinical success due to complex interactions within the epigenome and with genetic mutations and oncogenic pathways.

Purpose of the Study:

  • To review recent advancements in epigenome-centered treatment strategies for colorectal cancer.
  • To highlight the potential of epigenetic-associated therapies, emphasizing the need for biomarker integration and context-dependent reprogramming.

Main Methods:

  • Literature review of recent advances in epigenetic therapies for CRC.
  • Analysis of the interplay between epigenetic modifications, genetic mutations, and therapeutic resistance.

Main Results:

  • Epigenetic drugs alone have limited efficacy in CRC treatment.
  • Combination therapies involving epigenetic drugs, immune checkpoint inhibitors, monoclonal antibodies, and chemotherapy show promise.
  • Biomarker integration and understanding cellular states are crucial for effective epigenetic therapy.

Conclusions:

  • Epigenome-centered strategies are essential for overcoming CRC progression and drug resistance.
  • Combination regimens targeting epigenetic vulnerabilities alongside other therapeutic modalities are recommended.
  • Future epigenetic therapies require tailored approaches based on biomarkers and cellular context for optimal reprogramming.
Keywords:
DNA methylationcolorectal cancerdrug resistanceepigenetic reprogrammingepigenetic therapyhistone modificationsimmunotherapy sensitization

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