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Updated: Aug 5, 2026
05:55
Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
Published on: September 27, 2024
Multifocal Glucocorticoid-Associated Osteonecrosis: Clinical Characteristics and Systemic Molecular Features
Kosuke Arita1, Tomohiro Shimizu1, Hotaka Ishizu1
1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Biomedicines
|July 28, 2026
Summary
Multifocal osteonecrosis, a severe form of glucocorticoid-associated osteonecrosis, is linked to systemic conditions like hematologic diseases and skin issues. Proteomic analysis reveals vascular and coagulation pathway alterations in multifocal cases.
Area of Science:
- Orthopedics
- Rheumatology
- Genomics
Background:
- Multifocal osteonecrosis (three or more sites) is a severe manifestation of glucocorticoid-associated osteonecrosis.
- It may be linked to underlying systemic conditions.
- This study investigates its clinical and proteomic characteristics.
Purpose of the Study:
- To characterize multifocal osteonecrosis (MGO) in patients with glucocorticoid-associated osteonecrosis (GO).
- To identify clinical factors associated with MGO.
- To explore serum proteomic profiles in MGO compared to GO and osteoarthritis.
Main Methods:
- Analysis of 107 patients undergoing surgery for femoral head osteonecrosis.
- Whole-body MRI for multifocal lesion detection.
- Serum proteomic profiling (nanoLC-MS/MS) and multivariate logistic regression.
Main Results:
- Multifocal osteonecrosis (MGO) occurred in 29% of patients.
- MGO patients were younger and received higher glucocorticoid doses.
- Hematologic diseases and skin manifestations were independently associated with MGO.
Conclusions:
- Multifocal osteonecrosis is associated with systemic clinical backgrounds.
- Exploratory proteomic analysis revealed altered patterns in fibrinolysis, coagulation, inflammation, and vascular homeostasis in MGO.
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