Redox Imbalance and Coronary Complexity Linking Oxidative Stress Biomarkers to SYNTAX II Score in Acute Coronary
Ramazan Düz1, Fethullah Kayan2, Salih Çibuk3
1Department of Cardiology, Faculty of Medicine, Yüzüncü Yıl University, Van 65000, Turkey.
Insights
Oxidative stress biomarkers are linked to coronary artery disease complexity in acute coronary syndrome patients. Higher SYNTAX II scores correlate with increased levels of both oxidant and antioxidant markers.
Area of Science:
- Cardiology
- Biochemistry
- Pathophysiology
Background:
- Acute coronary syndrome (ACS) pathogenesis involves lipoprotein metabolism, inflammation, and oxidative stress (OS).
- The link between OS biomarkers and coronary artery disease (CAD) complexity, assessed by the SYNTAX II score, needs further clarification.
Purpose of the Study:
- To evaluate serum OS biomarkers in newly diagnosed ACS patients.
- To investigate the association between these biomarkers and the SYNTAX II score.
Main Methods:
- Retrospective, single-center observational study of 60 ACS patients.
- Serum levels of superoxide dismutase (SOD), advanced oxidation protein products (AOPP), glutathione, catalase, and malondialdehyde (MDA) were measured.
- Correlation and regression analyses assessed associations with the SYNTAX II score.
Main Results:
- The SYNTAX II score positively correlated with SOD, AOPP, glutathione, catalase, and MDA.
- Higher SYNTAX II scores were associated with increased age, female sex, and potassium levels.
- Elevated oxidant and antioxidant biomarker levels were observed in patients with higher SYNTAX II scores.
Conclusions:
- Serum oxidative stress biomarkers are associated with coronary artery disease complexity in ACS patients.
- These findings highlight the role of oxidative stress in the pathophysiology of ACS and CAD severity.
Abstract:
Background: Lipoprotein metabolism, inflammation, and oxidative stress (OS) play interconnected roles in the pathogenesis of acute coronary syndrome (ACS). However, the relationship between oxidative stress biomarkers and coronary artery disease (CAD) complexity, particularly as assessed by the SYNTAX II score, remains incompletely understood. This study aimed to evaluate serum levels of oxidative stress-related biomarkers and to investigate their association with the SYNTAX II score in patients with newly diagnosed ACS. Methods: This was a retrospective, single-center observational study. A total of 60 patients with newly diagnosed ACS who underwent percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) were consecutively enrolled. Serum levels of superoxide dismutase (SOD), advanced oxidation protein products (AOPP), glutathione, catalase, and malondialdehyde (MDA) were measured using ELISA methods. Associations between oxidative stress markers and the SYNTAX II score were analyzed using correlation and regression analyses. Results: Median levels of SOD, AOPP, and glutathione were 261.0 (244.18-324.86) U/L, 23.81 (22.62-25.80) ng/mL, and 6.08 (5.28-11.46) ng/mL, respectively. Mean catalase and MDA levels were 339.07 ± 44.81 pg/mL and 0.66 ± 0.07 mmol/L. The SYNTAX II score was positively correlated with SOD, AOPP, glutathione, catalase, and MDA, as well as with age, female sex, and potassium levels, while it was negatively correlated with hemoglobin, creatinine clearance, and left ventricular ejection fraction (all p < 0.05). Patients with higher SYNTAX II scores demonstrated elevated levels of both oxidant and antioxidant biomarkers. Conclusions: Oxidative stress-related biomarkers were associated with the SYNTAX II score in patients with newly diagnosed ACS.
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:30Acute Coronary Syndrome I: Introduction
01:30Coronary Artery Disease I: Introduction
01:26Acute Coronary Syndrome V: Nursing Management
01:26Coronary Artery Disease II: Pathophysiology