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Published on: May 5, 2022
Mitochondrial Dysfunction: From Molecular Mechanisms to Modern Approaches for Basic and Clinical Research
Tatiana V Kirichenko1,2, Yaroslav D Tolkachev2, Stepan M Bessonov2
1Petrovsky National Research Centre of Surgery, 119435 Moscow, Russia.
Biomedicines
|July 28, 2026
Summary
Mitochondrial dysfunction is linked to chronic diseases. Research explores its role and assessment methods for new diagnostics and treatments.
Area of Science:
- Cellular Biology
- Mitochondrial Biology
- Pathogenesis Research
Background:
- Mitochondria are crucial for cellular functions like energy metabolism and apoptosis.
- Mitochondrial dysfunction is implicated in chronic diseases including metabolic disorders, cardiovascular disease, neurodegeneration, and cancer.
- Understanding mitochondrial dynamics, mitophagy, biogenesis, mtDNA damage, and reactive oxygen species is key to disease insights.
Purpose of the Study:
- To review the pathogenetic role of mitochondrial dysfunction in chronic diseases.
- To summarize current methods for evaluating mitochondrial dysfunction.
- To explore integrating biomarkers and developing targeted therapies.
Main Methods:
- Literature review of studies on mitochondrial dysfunction in chronic diseases.
- Analysis of current assessment methods for mitochondrial function.
- Synthesis of findings for diagnostic and therapeutic implications.
Main Results:
- Mitochondrial dysfunction is a common factor in numerous chronic diseases.
- Various methods exist for assessing mitochondrial health, but a comprehensive approach is needed.
- Research highlights potential diagnostic markers and therapeutic targets related to mitochondria.
Conclusions:
- Mitochondrial dysfunction is a significant contributor to chronic disease pathogenesis.
- Reliable and comprehensive assessment of mitochondria is crucial for clinical application.
- Further research can lead to improved diagnostic strategies and mitochondria-targeted treatments.
Keywords:
cardiovascular diseaseflow cytometrymetabolic syndromemitochondrial dysfunctionmtDNAneurodegenerative diseasesoncologyseahorse assaytranscriptome analysisMore Related Videos
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