Mandibular Advancement Device Therapy in 182 DISE-Selected Adults with Moderate-to-Severe Obstructive Sleep Apnea: A...

Area of Science:

• Sleep Medicine
• Medical Devices
• Respiratory Medicine

Background:

• Obstructive sleep apnea (OSA) is a common respiratory disorder.
• Drug-induced sleep endoscopy (DISE) aids in preselecting patients for treatment.
• Mandibular advancement devices (MADs) are an option for OSA management.

Purpose of the Study:

• To evaluate the effectiveness of MAD treatment in adults with moderate-to-severe OSA preselected by DISE.
• To assess changes in apnea-hypopnea index (AHI), snoring, and sleepiness scores.

Main Methods:

• Retrospective observational cohort study of 182 adult OSA patients (AHI ≥ 15).
• Patients received custom-made MADs titrated to symptom relief or limits.
• Outcomes assessed via home polygraphy (Level-3) post-treatment.

Main Results:

• Mean AHI decreased significantly from 24.4 to 7.1 (p < 0.0001), a 68.6% reduction.
• Snoring loudness and Epworth Sleepiness Scale (ESS) scores significantly improved.
• 75.8% of participants achieved treatment success (AHI < 10 and ≥50% improvement).

Conclusions:

• MAD therapy is effective in reducing AHI, snoring, and sleepiness in DISE-preselected moderate-to-severe OSA patients.
• The study reflects real-world effectiveness within a clinical care pathway.
• Findings support MADs as a viable treatment option for this patient population.