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Radiomodulation-The Final Frontier of Radiosurgery?
Fred C Lam1, Evan Chau2, Yazhen Shi3
1Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Brain Sciences
|July 28, 2026
Summary
Stereotactic radiosurgery (SRS) uses focused radiation to treat brain conditions. Emerging research explores radiomodulation, using focused radiation to alter neural circuits for neurological disorders.
Area of Science:
- Neurology
- Neurosurgery
- Radiation Oncology
Background:
- Stereotactic radiosurgery (SRS) effectively treats brain tumors and vascular lesions using focused ionizing radiation (IR).
- The concept of radiomodulation, using focused IR to modulate neural circuits, is emerging for neurological conditions.
- Current applications include essential tremor, trigeminal neuralgia, and psychiatric disorders.
Purpose of the Study:
- To conduct a scoping review of evidence supporting focused IR for neural circuit modulation.
- To examine the neurophysiological mechanisms underlying radiomodulation.
- To identify knowledge gaps and unmet needs for clinical application of radiomodulation.
Main Methods:
- Scoping review of existing literature.
- Analysis of neurophysiological mechanisms.
- Identification of research gaps and clinical limitations.
Main Results:
- Evidence supports focused IR's potential for neural circuit modulation.
- Understanding of radiomodulation's neurophysiological mechanisms is developing.
- Significant knowledge gaps hinder widespread human application.
Conclusions:
- Radiomodulation shows promise as a non-invasive treatment for neurological conditions.
- Further rigorous research is essential to validate radiomodulation's efficacy and safety.
- Radiomodulation could represent a versatile, tunable therapeutic frontier.
