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Mapping TriNetX-Based Real-World Evidence Publications by Clinical Domain and Study Purpose, 2018-2025: A
Min-Chih Hsieh1, Ming-Chi Lu2,3, Malcolm Koo4,5
1Division of Obstetrics and Gynecology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 622401, Taiwan.
Healthcare (Basel, Switzerland)
|July 28, 2026
Summary
Publications using federated electronic health record networks like TriNetX have rapidly expanded. Research has diversified across clinical domains, with a notable shift from COVID-19 studies to other areas like cardiometabolic disease.
Area of Science:
- Health Informatics
- Bibliometrics
- Real-World Evidence Generation
Background:
- Federated electronic health record (EHR) networks are crucial for real-world evidence (RWE) generation.
- Publication patterns for the TriNetX platform are not well-understood.
- This study analyzes the characteristics and trends of TriNetX-based publications.
Purpose of the Study:
- To map and characterize Web of Science-indexed articles mentioning TriNetX.
- To examine the distribution of these articles across clinical domains and study purposes.
- To identify trends and gaps in TriNetX-utilized research.
Main Methods:
- Searched Web of Science Core Collection (2018-2025) for articles with 'TriNetX'.
- Analyzed bibliometric indicators, journal sources, citation impact, and keyword co-occurrence using R and VOSviewer.
- Classified clinical domains and study purposes using a rule-based dictionary and validated with Scopus data.
Main Results:
- 1573 articles were identified, with rapid annual growth from 2018 to 2025.
- Top contributing countries were the United States and Taiwan; COVID-19 research dominated highly cited studies.
- Research focus shifted from pandemic topics to mortality, cardiometabolic disease, and medication outcomes; risk/prognosis studies were most frequent.
Conclusions:
- TriNetX publications show rapid expansion and diversification across clinical fields.
- Domain-purpose mapping reveals research concentration and sparsity, not necessarily evidence gaps.
- Future research could focus on comparative effectiveness, long-term safety, and phenotype validation where TriNetX is suitable.
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