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Post-Thyroidectomy Nausea and Vomiting Using Continuous Remifentanil Infusion During Emergence Depending on the
1Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, 807, Hoguk-ro, Buk-gu, Daegu 41404, Republic of Korea.
Medicina (Kaunas, Lithuania)
|July 28, 2026
Summary
Sevoflurane and desflurane equally impacted postoperative nausea and vomiting (PONV) after thyroidectomy. Desflurane offered faster recovery and alertness without increased side effects compared to sevoflurane.
Area of Science:
- Anesthesiology
- Surgical Recovery
- Patient Outcomes
Background:
- Post-thyroidectomy retching from nausea and vomiting (PONV) poses risks like wound rupture and bleeding.
- Inhaled anesthetics, common in thyroidectomy, may elevate PONV risk.
- Continuous remifentanil infusion until extubation is used during emergence.
Purpose of the Study:
- To compare PONV incidence and recovery patterns between sevoflurane and desflurane.
- To evaluate the impact of these anesthetics on early recovery post-thyroidectomy.
- To assess safety and side effects associated with each anesthetic during emergence.
Main Methods:
- Retrospective cohort study of 70 female patients undergoing thyroidectomy.
- Patients were divided into sevoflurane (n=35) and desflurane (n=35) groups.
- Remifentanil infusion maintained at 2 ng/mL effect-site concentration during emergence.
Main Results:
- PONV incidence was 20% in both sevoflurane and desflurane groups.
- Desflurane group showed significantly faster recovery of consciousness and extubation times.
- Desflurane patients were more alert post-extubation, with shorter postanesthesia care unit stays.
- No significant differences in hemodynamics, pain, or sedation between groups.
Conclusions:
- Sevoflurane and desflurane do not differ in acute PONV incidence after thyroidectomy with remifentanil infusion.
- Desflurane facilitates quicker early recovery without additional adverse effects compared to sevoflurane.
- Anesthetic choice did not alter acute recovery profiles between the two agents.
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