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Updated: Aug 5, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
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Acral Peeling Skin Syndrome: More than a Rare Genodermatosis Affecting Not Only the Skin
Aleksandra Kuźniak-Jodłowska1,2, Jakub Szewczyk3, Magdalena Jałowska1
1Department of Dermatology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-356 Poznan, Poland.
Medicina (Kaunas, Lithuania)
|July 28, 2026
Summary
Atomic force microscopy revealed nanoscale differences in hair cuticle morphology in children with Acral Peeling Skin Syndrome (APSS). This study provides foundational data on APSS hair shaft characteristics.
Area of Science:
- Dermatology
- Genetics
- Nanotechnology
Background:
- Acral Peeling Skin Syndrome (APSS) is a rare genodermatosis.
- Hair abnormalities in APSS are not well-documented, especially in pediatric cases.
Purpose of the Study:
- To characterize hair shaft morphology in pediatric APSS patients using atomic force microscopy (AFM).
- To investigate age-related differences in hair morphology in APSS.
Main Methods:
- Collected hair samples from two pediatric APSS patients and age-matched controls.
- Analyzed hair cuticle morphology using AFM at nanoscale resolution.
- Quantified cuticle scale dimensions and deviations.
Main Results:
- Identified distinct nanoscale differences in hair cuticle morphology in APSS patients compared to controls.
- Observed variations in cuticle scale step height, length, and width.
Conclusions:
- This is the first AFM characterization of hair shaft morphology in pediatric APSS.
- Findings establish a basis for further research into APSS hair abnormalities.
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