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A Multifunctional Double-Array Petals Flower-Shaped Microfluidic Chip Combining Affinity and Physical Properties in
Hongmei Chen1,2, Peng Zhang1, Guosheng Peng1
1School of Mathematics and Physics of Science and Engineering, Anhui University of Technology, Maanshan 243002, China.
Micromachines
|July 28, 2026
Summary
This study introduces a novel microfluidic chip for isolating circulating tumor cells (CTCs). The chip effectively captures rare CTCs from blood, aiding cancer diagnosis and treatment monitoring.
Area of Science:
- Biomedical Engineering
- Cancer Research
- Microfluidics
Background:
- Circulating tumor cells (CTCs) are crucial biomarkers for cancer prognosis and diagnosis.
- Separating CTCs from blood is challenging due to their rarity and heterogeneity.
Purpose of the Study:
- To design and validate a novel microfluidic chip for efficient and high-purity isolation of CTCs.
- To combine affinity and physical properties for enhanced CTC capture.
Main Methods:
- A double-array petal flower-shaped microfluidic chip with three sequential capture structures.
- Utilizing convex structures, S-shaped microcolumns, and elliptical microposts for multi-angle, multi-time capture.
- Conducting simulations to analyze fluid dynamics, pressure, streamlines, and shear rates.
Main Results:
- The chip design theoretically demonstrates high capture rates and purity for CTCs.
- Simulations provide validation for the chip's effectiveness in capturing CTCs.
- The design aims to preserve cell viability for subsequent analysis.
Conclusions:
- The developed microfluidic chip offers a promising approach for CTC isolation.
- This technology can facilitate CTC enumeration, clinical analysis, and cancer therapy evaluation.
