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Melioidosis Seroprevalence in Animals: Systematic Review and Meta-Analysis
Jongkonnee Thanasai1, Anchalee Chittamma2, Supphachoke Khemla3
1Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand.
Life (Basel, Switzerland)
|July 28, 2026
Summary
Seroprevalence of Burkholderia pseudomallei, the cause of melioidosis, is widespread in animals globally. Geographic location and diagnostic methods significantly influence B. pseudomallei exposure rates in wildlife and livestock.
Area of Science:
- Veterinary Epidemiology
- Microbiology
- One Health
Background:
- Burkholderia pseudomallei causes melioidosis in diverse animal species.
- Environmental contamination with B. pseudomallei is a known issue.
- Global B. pseudomallei seroprevalence in animals is not well-characterized.
Purpose of the Study:
- To systematically review and meta-analyze the global seroprevalence of B. pseudomallei in animals.
- To identify factors influencing seroprevalence, including animal group, geography, and diagnostic methods.
Main Methods:
- Systematic review and meta-analysis following PRISMA guidelines.
- Searched PubMed, Embase, and Scopus for observational studies.
- Random-effects meta-analysis to estimate pooled prevalence; subgroup analyses performed.
Main Results:
- Included 20 studies with 78,914 animals; pooled seroprevalence was 11% (95% CI: 6-19%).
- Wildlife (16%) and livestock (11%) showed significant seroprevalence.
- Higher prevalence observed in North America (18%) and Southeast Asia (10%); heterogeneity noted.
Conclusions:
- B. pseudomallei exposure is widespread in animal populations globally.
- Geographic location and diagnostic methods impact seroprevalence.
- Standardized diagnostics and enhanced surveillance are crucial for One Health approaches to melioidosis.
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