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Published on: May 10, 2024
Association Between Eosinophilic Esophagitis and Coded Ocular Diagnoses: A Retrospective Cohort Study
Yun-Feng Li1, Yu-Jung Su2, Hui-Chin Chang1,3,4
1School of Medicine, Chung Shan Medical University, Taichung 402302, Taiwan.
Life (Basel, Switzerland)
|July 28, 2026
Summary
Eosinophilic esophagitis (EoE) is linked to increased risks of various eye conditions, including visual disturbances, cataracts, and glaucoma. This study highlights potential associations between EoE and ocular diagnoses, warranting further investigation into underlying mechanisms.
Area of Science:
- Ophthalmology
- Gastroenterology
- Immunology
Background:
- Eosinophilic esophagitis (EoE) is an immune-mediated disease recognized as a systemic inflammatory condition.
- The association between EoE and subsequent ocular diagnoses is not well-established in large-scale studies.
Purpose of the Study:
- To investigate the association between a diagnosis of eosinophilic esophagitis (EoE) and the subsequent development of coded ocular conditions.
- To analyze large-scale electronic health records to identify potential links between EoE and various eye diagnoses.
Main Methods:
- Retrospective cohort study using the TriNetX Global Collaborative Network (2005-2024).
- Included adults (≥18 years) with EoE (exposure) and controls without EoE, matched using propensity scores (1:1).
- Exclusion criteria: prior ocular disease, malignancy, or death. Ocular events within 3 months of index date were excluded.
Main Results:
- The study included 64,613 patients in each cohort post-matching.
- EoE diagnosis was associated with increased subsequent occurrence of visual disturbance/blindness (HR=1.52), refractive disorders (HR=1.32), lacrimal disorders (HR=1.50), cataract (HR=1.64), glaucoma (HR=1.46), and vitreous/globe disorders (HR=1.90).
- Findings for broad categories like visual disturbance require cautious interpretation due to potential detection/coding biases.
Conclusions:
- This large EHR study suggests an association between EoE diagnosis and a higher incidence of several coded ocular conditions.
- The observed associations are exploratory and do not confirm direct causal or mechanistic links.
- Further research is needed, especially for broad outcomes susceptible to detection bias.
