Copper Complexes: Emerging Micro- and Nanosystems for Dermatological Treatment

The use of copper complexes as pharmacotherapy represents an emerging strategy with multiple therapeutic advantages, including their enhanced bioavailability, antimicrobial activity, and ability to participate in diverse cellular processes. These molecules, combined with micro- and nanosystems, offer an advanced approach to the sustained delivery of copper, optimizing its absorption while potentially reducing adverse effects. In this review, we highlight the application of copper complexes reported in recent studies for dermatological diseases and infection management. Furthermore, evidence indicates that copper promotes cell regeneration in wounds and burns, accelerating wound healing. However, their clinical translation requires careful consideration of copper homeostasis, as dysregulation may lead to oxidative stress and toxicity. In perspective, the combination of micro- and nanoformulations with specific copper complexes offers new opportunities for tailored therapies, as well as for the optimization of pharmacokinetics, positioning copper as a multifunctional therapeutic agent in regenerative and supplementation medicine. However, further investigation is required to establish safety, optimal dosing, and long-term effects.