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Eudragit-Based Nanoparticles for Oral Drug Delivery
Filipa Bettencourt1, Patrícia C Pires2,3,4,5, Francisco Veiga1,2
1Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Pharmaceutics
|July 28, 2026
Summary
Eudragit-based nanoparticles offer advanced oral drug delivery by controlling release and targeting the gastrointestinal tract. These systems enhance drug stability and therapeutic outcomes for improved patient compliance.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Nanotechnology
Background:
- Oral drug delivery systems are crucial for patient compliance and therapeutic efficacy.
- Controlled and targeted drug release is essential for minimizing adverse effects.
- Eudragit-based nanoparticles show promise for enhancing oral drug delivery.
Purpose of the Study:
- To review the application of Eudragit-based nanoparticles in oral drug delivery.
- To analyze formulation composition, preparation, properties, and release mechanisms.
- To highlight advances, applications, and challenges of these nanosystems.
Main Methods:
- Comprehensive literature review of Eudragit-based nanoparticulate systems.
- Analysis of formulation strategies including inorganic nanoparticles, nanocrystals, lipid-based carriers, and polymeric nanoparticles.
- Evaluation of in vitro, ex vivo, and in vivo characterization methods.
Main Results:
- Eudragit nanoparticles offer pH-dependent solubility, mucoadhesion, and tunable drug loading.
- These systems enhance drug stability, control release profiles, and enable site-specific targeting.
- Polymeric materials impact therapeutic outcomes through controlled-release strategies.
Conclusions:
- Eudragit-based nanoparticles are versatile platforms for oral drug delivery.
- Further research is needed to overcome challenges for robust clinical application.
- These nanosystems hold potential for improving oral drug bioavailability and efficacy.
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