Related Experiment Video

Updated: Aug 5, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Congenital Cytomegalovirus Infection in Pregnancy: Challenges in Early Diagnosis, Reinfection, and Secondary

Cinzia Auriti1, Chiara Maddaloni2, Sara Ronci2

  • 1Medicine Interdepartmental Faculty, Saint Camillus International University of Health and Medical Sciences, 00131 Rome, Italy.

Viruses
|July 28, 2026
PubMed

Insights

Cytomegalovirus (CMV) is a common pediatric infection with serious risks. Early diagnosis and intervention, including universal newborn screening, are crucial for preventing long-term disabilities like hearing loss.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Cytomegalovirus (CMV) is a prevalent congenital and early-life infection globally.
  • Maternal primary CMV infection poses a significant risk for transplacental transmission and adverse fetal/neonatal outcomes.
  • CMV infection in children can lead to diverse health issues, including neurodevelopmental impairment and hearing loss.

Purpose of the Study:

  • To highlight the clinical importance of timely maternal diagnosis and differentiating primary from recurrent CMV infection.
  • To emphasize the need for integrated prenatal, neonatal, radiological, and audiological assessments.
  • To discuss the role of antiviral strategies and universal newborn screening in managing pediatric CMV.

Main Methods:

  • Clinical review of Cytomegalovirus (CMV) in pediatric populations.
  • Analysis of diagnostic and assessment strategies for congenital and early-life CMV.
  • Evaluation of prevention and treatment approaches, including antiviral therapies and screening.

Main Results:

  • Timely maternal diagnosis and differentiating infection types are critical for managing CMV.
  • A comprehensive assessment framework including prenatal, neonatal, and audiological evaluations is necessary.
  • Antiviral treatments and universal newborn screening can improve early detection and reduce long-term sequelae.

Conclusions:

  • A multidisciplinary approach and early intervention are essential for optimizing outcomes in pediatric CMV infections.
  • Universal newborn screening for CMV is a valuable strategy for early detection and reducing long-term disability.
  • Integrated management strategies are key to preventing, diagnosing, and treating CMV effectively in infants and children.

Keywords:
CMVantiviral therapymaternal serologynewbornplacental infectionsensorineural hearing lossvertical transmission

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