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Updated: Aug 5, 2026
06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Rotavirus Infection as a Contributor to Early-Onset Type 1 Diabetes: Review and Recommendations
Mary A M Rogers1, Scott O Rogers2
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Viruses
|July 28, 2026
Summary
Rotavirus infection in young children increases the risk of developing type 1 diabetes. Rotavirus vaccination is linked to reduced incidence rates, highlighting its importance for prevention.
Area of Science:
- Pediatric infectious diseases
- Endocrinology
- Immunology
Background:
- Rotavirus is a leading cause of acute gastroenteritis in children.
- Infections can extend beyond the gut, affecting organs like the pancreas.
- Pancreatic beta islet cell damage can lead to type 1 diabetes mellitus.
Purpose of the Study:
- To review scientific evidence linking rotavirus infection to early-onset type 1 diabetes.
- To evaluate the impact of rotavirus vaccination on type 1 diabetes incidence.
Main Methods:
- Narrative review of epidemiologic, animal, and laboratory research.
- Analysis of rotavirus infection and type 1 diabetes incidence data.
- Comparison of vaccine types (monovalent vs. pentavalent).
Main Results:
- Rotavirus infection elevates the risk of type 1 diabetes in children under five.
- Rotavirus vaccination is associated with decreased type 1 diabetes rates.
- Pentavalent rotavirus vaccine shows a potentially stronger protective effect.
Conclusions:
- Rotavirus infection is a significant risk factor for early-onset type 1 diabetes.
- Rotavirus vaccination is a key preventive strategy.
- Ongoing surveillance and discussion of vaccine benefits are crucial due to vaccine hesitancy.
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