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Published on: April 6, 2019
Angelica sinensis as a Multi-Targeted Natural Product Candidate: Constituent-Specific Mechanisms, Exposure
Jialian Song1, Hui Sun1, Zhineng Li1
1State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China.
Angelica sinensis (Danggui) shows potential in traditional medicine, but its therapeutic effects require careful evaluation of specific compounds like phthalides and polysaccharides, considering their bioavailability and exposure levels for clinical relevance.
Area of Science:
- Pharmacology
- Ethnomedicine
- Translational Science
Background:
- Angelica sinensis (Danggui) is a traditional East Asian medicinal herb with diverse reported effects.
- Its complex chemical composition necessitates a constituent-specific evaluation for therapeutic potential.
Purpose of the Study:
- To critically review literature on Angelica sinensis up to May 2026.
- To reappraise its therapeutic effects through a constituent-specific and exposure-relevant framework.
Main Methods:
- Focused on key constituents: phthalides, ferulic acid-related phenolic acids, and polysaccharides.
- Evaluated literature considering chemical stability, oral exposure, and in vitro concentration relevance.
- Assessed clinical evidence for single-herb and multi-herb preparations.
Main Results:
- Phthalides show neurovascular benefits but have limited oral exposure.
- Phenolic acids are linked to anti-inflammatory effects, but often studied at non-plausible concentrations.
- Polysaccharides are associated with hematopoietic and immune support, but structural variability hinders comparisons.
- Clinical evidence for single-herb Angelica sinensis is limited, with most data from multi-herb formulas.
Conclusions:
- Distinguishing constituent-specific mechanisms is crucial for evaluating Angelica sinensis.
- Exposure plausibility and attribution directness are key factors for translational potential.
- Further research is needed to clarify the clinical utility of Angelica sinensis based on robust evidence.
