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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
Challenges and Strategies in Advancing miRNA-based Cancer Therapeutics
W M Farhan Syafiq B W M Nor1, Chung Lip Yong2, Syed Mahmood3
1Department of Pharmacology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Abstract:
The advancement of targeted cancer therapy has driven the exploration of cancer-associated miRNA modulation to achieve specific therapeutic outcomes. Despite similarities to other oligonucleotide therapeutics, miRNA-based approaches present unique challenges due to the biological complexity, including rapid degradation, poor tumour tissue penetration, and potential immunotoxicity. To address this limitation, numerous chemical modifications and advanced nanodelivery strategies have been developed and evaluated across preclinical and clinical settings. Overall, while significant progress has been made, optimising stability, delivery efficiency, and safety remain critical to fully realise the clinical potential of miRNA-based cancer therapeutics.
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