Multimodal Treatment for Female Primary Urethral Carcinoma: A Three-Case Series Utilizing Robot-Assisted Radical
Yuya Oishi1,2, Hiromitsu Watanabe1, Shinya Watanabe1
1Department of Urology Hamamatsu University School of Medicine Hamamatsu Japan.
Introduction:
Primary urethral carcinoma (PUC) is a rare malignancy, particularly in females, with no established standard treatment. We herein examined the clinical outcomes of three female patients who underwent multimodal therapy with robot-assisted radical cystectomy (RARC) and extended surgical resection.
Case Presentation:
Three female patients (45, 65, and 71 years) were diagnosed with PUC (adenocarcinoma, cT3N0M0; clear cell carcinoma, cT3N2M0; and squamous cell carcinoma, cT4N0M0). Two patients received cisplatin-based neoadjuvant chemotherapy. All patients underwent RARC with en bloc urethrectomy and extended resection of the anterior vaginal wall or pelvic fascia. One achieved a pathological complete response, one developed local recurrence due to a positive surgical margin, and two remained recurrence-free.
Conclusion:
Individualized multimodal strategies combining perioperative chemotherapy and extended surgical resection are crucial for managing locally advanced PUC in females.
