Multimodal Treatment for Female Primary Urethral Carcinoma: A Three-Case Series Utilizing Robot-Assisted Radical
Yuya Oishi1,2, Hiromitsu Watanabe1, Shinya Watanabe1
1Department of Urology Hamamatsu University School of Medicine Hamamatsu Japan.
IJU Case Reports
|July 28, 2026
Summary
Robot-assisted radical cystectomy (RARC) with extended resection offers a promising multimodal approach for treating advanced primary urethral carcinoma (PUC) in women. This strategy, combined with neoadjuvant chemotherapy, shows potential for recurrence-free survival in female patients.
Area of Science:
- Uro-oncology
- Surgical oncology
Background:
- Primary urethral carcinoma (PUC) is rare in females.
- No standard treatment exists for advanced PUC in women.
Purpose of the Study:
- To examine clinical outcomes of female patients with advanced PUC.
- To evaluate multimodal therapy including robot-assisted radical cystectomy (RARC) and extended resection.
Main Methods:
- Retrospective analysis of three female PUC patients.
- Multimodal therapy: neoadjuvant chemotherapy and RARC with en bloc urethrectomy and extended pelvic resection.
- Pathological response and recurrence rates were assessed.
Main Results:
- Patients aged 45, 65, and 71 with varying PUC subtypes and stages.
- One patient achieved pathological complete response.
- One patient had local recurrence; two remained recurrence-free post-treatment.
Conclusions:
- Individualized multimodal strategies are vital for advanced female PUC.
- Combining neoadjuvant chemotherapy with extended RARC is a viable approach.
