Urothelial Carcinoma With Pericardial Involvement: Report of Two Rare Cases and Literature Review

Urothelial carcinoma (UC) is the ninth most diagnosed cancer worldwide, and pericardial dissemination is uncommon. In this case report, we describe the case of a patient in a complete response after chemotherapy with cisplatin/gemcitabine and maintenance avelumab that presented with cardiac tamponade, posteriorly confirmed to be caused by pericardial involvement by UC, and the case of a patient with UC with peritoneal metastasis at diagnosis under carboplatin/gemcitabine treatment, whose disease progressed with pericardial metastasis. The clinical documentation of pericardial metastasis in living patients is rare, and the management of this condition is still not well defined. Therefore, the description of these cases is important to raise awareness of pericardial involvement as a possible manifestation of UC.