Variables Affecting Periprocedural Haemostatic Response in Patients With Haemophilia: Real-World Retrospective Study

Area of Science:

• Hematology
• Internal Medicine
• Clinical Trials

Background:

• Patients with haemophilia (PWH) are at increased risk of periprocedural bleeding during invasive procedures.
• Optimal haemostatic response (HR) is crucial for managing bleeding risk but depends on various patient- and procedure-related factors.

Purpose of the Study:

• To evaluate variables associated with haemostatic response (HR) in patients with haemophilia (PWH) undergoing invasive procedures.
• To identify factors influencing successful haemostasis in PWH during medical interventions.

Main Methods:

• Retrospective, single-centre study of invasive procedures in males with haemophilia A or B (2010-2025).
• Data collected included patient demographics, haemophilia characteristics, prophylaxis, and procedure details.
• Haemostatic response (HR) assessed using World Federation of Haemophilia criteria (good/excellent vs. fair/poor).

Main Results:

• 158 procedures in 61 patients; 95.6% achieved good/excellent HR.
• Fair/poor HR was significantly higher in patients weighing >100 kg (27.3%) compared to other weight groups (p=0.003).
• Major procedures showed a trend towards higher fair/poor HR (10.5%) versus minor procedures (2.5%), though not statistically significant (p=0.058).

Conclusions:

• High body weight is a potential risk factor for suboptimal haemostatic response (HR) in patients with haemophilia (PWH) undergoing invasive procedures.
• Findings support the need for targeted strategies, including weight management, to optimize HR and reduce bleeding risks in overweight or obese PWH.