Related Experiment Video

Updated: Aug 5, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

Bibliometric Trends in Inflammasome‑Driven Pyroptosis and Cardiovascular Disease

Yupei Tan1, Wei Wang1, Rui Qiang1

  • 1Beijing Hospital of Traditional Chinese Medicine, Shunyi Hospital, Beijing, People's Republic of China.

Journal of Inflammation Research
|July 28, 2026
PubMed

Insights

This study maps inflammasome-driven pyroptosis research in cardiovascular disease (CVD). NLRP3 inflammasome is central, with emerging focus on pyroptosis and ferroptosis crosstalk for future clinical trials.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Cell Death Mechanisms

Background:

  • Pyroptosis, an inflammatory programmed cell death, is crucial in cardiovascular diseases (CVDs) like hypertension, atherosclerosis, and heart failure.
  • Inflammasome activation drives pyroptosis, a rapidly growing research area within CVD.
  • No prior bibliometric analysis has comprehensively synthesized inflammasome-driven pyroptosis research in CVD.

Purpose of the Study:

  • To conduct the first bibliometric analysis of inflammasome-driven pyroptosis research in cardiovascular disease.
  • To systematically map the evolution, trends, and key areas of this research field.
  • To identify emerging hotspots and future research directions.

Main Methods:

  • Bibliometric and visual analyses were performed on 4,511 documents (1998-2025) from the Web of Science Core Collection.
  • CiteSpace and VOSviewer were utilized to analyze publication trends, country/region, institutions, authors, journals, and keywords.
  • Keyword co-occurrence analysis identified research clusters and emerging trends.

Main Results:

  • China leads in publications (50.1%), while the US has the highest h-index (147). Harvard University is a leading institution.
  • The NLRP3 inflammasome is the most frequently studied and cited topic.
  • Emerging research frontiers include the interplay between pyroptosis and ferroptosis, with recent bursts in 2024-2025.

Conclusions:

  • NLRP3 inflammasome is the core focus in inflammasome-driven pyroptosis research in CVD.
  • Research is shifting from basic mechanisms to translational applications.
  • Future research should explore pyroptosis-ferroptosis crosstalk and patient stratification for clinical trials.
Abstract

Keywords:
CVDNLRP3bibliometricinflammasomepyroptosis

More Related Videos

LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation06:12

LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation

Published on: May 3, 2024

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages08:41

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages

Published on: April 6, 2022

Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Inflammation01:38

Inflammation

Overview
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...