Related Experiment Video
Updated: Aug 5, 2026
10:49
Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
Multifunctional Polyphenol-Polymer Nanocomposite Hydrogel Targeting Inflammation, Oxidative Stress, and Infection in
Yuefei Zhu1,2, Na Yan1, Yongqiang Xiao1,3
1Department of Biomedical Engineering, Columbia University, New York, New York, USA.
Small (Weinheim an Der Bergstrasse, Germany)
|July 28, 2026
Summary
A new nanoplatform with tannic acid (TA)-complexed nanoparticles in a thermoresponsive hydrogel effectively treats chronic diabetic wounds by reducing inflammation, oxidative stress, and hyperglycemia, accelerating healing.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing Research
Background:
- Chronic diabetic wounds suffer from persistent inflammation, oxidative stress, and hyperglycemia, hindering healing.
- Current treatments often fail to address these multiple pathological factors simultaneously.
- This necessitates innovative therapeutic strategies for effective diabetic wound management.
Purpose of the Study:
- To develop a multifunctional nanoplatform for simultaneous treatment of key pathological factors in diabetic wounds.
- To create tannic acid (TA)-complexed chitosan-polyethylenimine-phenylboronic acid (CPB-TA) nanoparticles within a thermoresponsive hydrogel.
- To evaluate the therapeutic efficacy of this nanoplatform in preclinical models of diabetic wounds.
Main Methods:
- Fabrication of CPB-TA nanoparticles and their incorporation into a thermoresponsive P(NIPAm-co-AAc) hydrogel.
- In vitro assessment of nanoparticle functionalities including cfDNA scavenging, antioxidant activity, glucose regulation, and cellular effects (macrophage polarization, endothelial cell protection, antibacterial activity).
- In vivo evaluation of the CPB-TA@hydrogel in non-infected and Staphylococcus aureus-infected diabetic mouse models for wound closure, re-epithelialization, and collagen deposition.
Main Results:
- CPB-TA nanoparticles demonstrated dual cfDNA-scavenging and antioxidant properties, reducing inflammation and oxidative stress.
- The phenylboronic acid component effectively alleviated local hyperglycemia via reversible glucose capture.
- In vitro studies showed enhanced macrophage M2 polarization, endothelial cell protection, and antibacterial effects.
- In vivo application significantly accelerated wound healing, improved tissue regeneration, and increased collagen deposition in diabetic wound models.
Conclusions:
- The developed multifunctional nanoplatform offers a promising, mechanism-targeted approach for treating chronic diabetic wounds.
- Simultaneous targeting of inflammation, oxidative stress, hyperglycemia, and bacterial infection contributes to enhanced wound healing.
- This strategy represents a significant advancement in the development of advanced wound care technologies for complex wounds.
