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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
Clinical patterns and pathogenesis of bladder leiomyoma: a multicenter observational study
Lory Hage1, Mohamad Abou Chakra2, Michael A O'Donnell2
1Department of Medicine, Université Paris Cité, Paris, France. lory.hage@aphp.fr.
World Journal of Urology
|July 28, 2026
Summary
Bladder leiomyoma (BL) is often asymptomatic, with recurrence uncommon. Symptomatic patients may experience persistent lower urinary tract symptoms (LUTS), suggesting a personalized treatment approach for BL.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Bladder leiomyoma (BL) is a rare benign smooth muscle tumor of the bladder.
- Understanding BL characteristics is crucial for effective management.
- Previous studies on BL are limited by small sample sizes.
Purpose of the Study:
- To characterize clinical and tumor features of bladder leiomyoma.
- To identify etiological and prognostic factors for BL.
- To inform management strategies for bladder leiomyoma.
Main Methods:
- Retrospective analysis of 74 patients with histologically confirmed BL from 14 hospitals (1995-2025).
- Evaluation of associations between tumor characteristics, symptoms, management, and outcomes.
- Statistical tests and logistic regression were used, with p < 0.05 considered significant.
Main Results:
- The median age of patients was 60 years, with 55.4% being female. 48.6% were asymptomatic at diagnosis.
- Tumor size (median 21.0 mm) and location influenced surgical management (p=0.002).
- Recurrence occurred in 5.4%, and persistent LUTS in 17.6%; initial LUTS predicted recurrence and persistent symptoms.
Conclusions:
- This study presents the largest cohort of bladder leiomyoma to date.
- The high rate of asymptomatic cases suggests underdiagnosis.
- Persistent LUTS in initially symptomatic patients supports a personalized, conservative management approach for BL.
