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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
Clinical patterns and pathogenesis of bladder leiomyoma: a multicenter observational study
Lory Hage1, Mohamad Abou Chakra2, Michael A O'Donnell2
1Department of Medicine, Université Paris Cité, Paris, France. lory.hage@aphp.fr.
World Journal of Urology
|July 28, 2026
Summary
Bladder leiomyoma (BL) is often asymptomatic, with recurrence uncommon. Symptomatic patients may experience persistent lower urinary tract symptoms (LUTS) post-treatment, suggesting personalized management for bladder tumors.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Bladder leiomyoma (BL) is a rare mesenchymal tumor.
- Understanding BL clinical and tumor characteristics is crucial for effective management.
Purpose of the Study:
- To characterize clinical and tumor features of bladder leiomyoma (BL).
- To identify etiological and prognostic factors for guiding BL management strategies.
Main Methods:
- Retrospective analysis of 74 histologically confirmed BL cases from 14 hospitals (1995-2025).
- Statistical evaluation of associations between tumor characteristics, symptoms, management, and outcomes.
- Logistic regression used to identify predictive factors for recurrence and persistent symptoms.
Main Results:
- 66.2% of patients had metabolic syndrome criteria; 48.6% were asymptomatic.
- Tumor size and location influenced surgical management but not preoperative symptoms.
- Recurrence occurred in 5.4%, and persistent/worsening symptoms in 17.6%; initial LUTS predicted adverse outcomes.
Conclusions:
- This is the largest BL cohort to date, suggesting underestimation of true incidence.
- Personalized, conservative management is recommended, especially for symptomatic patients.
- Further research is needed to elucidate BL's biological mechanisms and optimize treatment.
