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Potential Role of Omega-3 Supplementation in Modulating Symptoms and Holter Parameters in Pediatric Inappropriate

Mohamed Ahmed El-Baz1, Somaia Abdel Samie El Wan1, Rodina Sobhy Mohamed1

  • 1Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt.

Indian Journal of Pediatrics
|July 28, 2026
PubMed

Insights

Omega-3 supplementation effectively improved heart rate control and heart rate variability in children with inappropriate sinus tachycardia. However, obesity and pre-hypertension may reduce treatment benefits.

Area of Science:

  • Cardiology
  • Pediatrics
  • Nutritional Science

Background:

  • Inappropriate sinus tachycardia (IST) is a condition affecting pediatric patients, impacting heart rate (HR) and heart rate variability (HRV).
  • Understanding effective interventions for IST in children is crucial for improving cardiovascular health outcomes.

Purpose of the Study:

  • To investigate the efficacy of omega-3 fatty acid supplementation in managing HR control and HRV in pediatric patients diagnosed with IST.
  • To assess the impact of omega-3s on clinical outcomes and identify factors influencing treatment response.

Main Methods:

  • A prospective randomized controlled trial was conducted with 60 children (12-16 years) diagnosed with IST.
  • Participants were assigned to either omega-3 supplementation or standard follow-up for 3 months.
  • Evaluations included 24-hour Holter monitoring for HR and HRV parameters (SDNN, RMSSD, pNN50) and clinical assessments.

Main Results:

  • The omega-3 group demonstrated significant reductions in maximum and average HR, alongside significant improvements in HRV indices (SDNN, RMSSD, pNN50).
  • The control group showed no significant changes in HR or HRV.
  • Clinical improvement was notably higher in the omega-3 group (63.3%) compared to controls (p < 0.001).
  • Obesity and pre-hypertension were associated with a poorer response to omega-3 therapy.

Conclusions:

  • Omega-3 supplementation offers a significant therapeutic benefit for HR control and HRV in pediatric IST patients.
  • Factors such as obesity and elevated blood pressure may attenuate the effectiveness of omega-3 treatment in this population.
Abstract

Keywords:
Autonomic regulationHeart rate variabilityInappropriate sinus tachycardiaOmega-3Pediatrics

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