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Updated: Aug 5, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

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Signaling pathways regulating cardiac regeneration

Jianan Li1, Minjie Hu1, Lu Ding1

  • 1Department of Cell Biology, Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Cell Regeneration (London, England)
|July 28, 2026
PubMed

Insights

This review explores cardiac regeneration, focusing on molecular pathways like Hippo/YAP and Wnt/β-catenin that control cardiomyocyte proliferation and repair. Advances in regenerative medicine offer hope for treating heart disease.

Area of Science:

  • Cardiovascular Research
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Cardiovascular diseases are the leading cause of death globally.
  • Cardiac regeneration is crucial for myocardial repair and addressing heart failure.
  • Understanding cardiomyocyte proliferation mechanisms is key to developing new therapies.

Purpose of the Study:

  • To review current advancements in cardiac regeneration.
  • To integrate knowledge on molecular mechanisms driving cardiomyocyte proliferation and myocardial repair.
  • To discuss challenges and emerging technologies in the field.

Main Methods:

  • Literature review of molecular mechanisms in cardiac regeneration.
  • Analysis of key signaling pathways (Hippo/YAP, Wnt/β-catenin, NRG1-ErbB, MAPK, Notch).
  • Examination of transcriptional regulators, extracellular matrix components, and growth factors involved.

Main Results:

  • Identified key signaling pathways orchestrating cardiomyocyte dedifferentiation, cell cycle re-entry, and tissue remodeling.
  • Highlighted the roles of specific regulators (Meis1, GATA4, Tbx20) and microenvironment factors.
  • Noted challenges in controlling proliferation, interspecies differences, and delivery methods.

Conclusions:

  • Emerging technologies like engineered grafts and mRNA systems show translational potential.
  • Future strategies require integrating multi-omics, biomaterials, and combinatorial approaches.
  • Bridging mechanistic insights with clinical applications is essential for advancing cardiac regeneration.
Keywords:
Cardiac regenerationCardiomyocyte proliferationCell cycle proteinsMetabolic reprogrammingSignaling pathwaysTherapeutic deliveryTranscriptional regulation

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