Related Experiment Video
Updated: Aug 5, 2026
03:49
Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System
Published on: September 20, 2018
Obesity and pelvic organ prolapse: Review
1Selçuk University Faculty of Medicine, Türkiye Obstetrics and Gynecology Department, Konya, Türkiye.
Obesity Pillars
|July 28, 2026
Summary
Obesity exacerbates pelvic organ prolapse (POP) through mechanical and molecular pathways, impacting women's health. Understanding these links is crucial for developing effective prevention and treatment strategies for obesity and POP.
Area of Science:
- Women's Health
- Public Health
- Gastroenterology
Background:
- Obesity is a significant public health issue affecting women's quality of life.
- Pelvic organ prolapse (POP) involves pelvic organ descent, influenced by obesity's mechanical and molecular factors.
Purpose of the Study:
- To review the relationship between obesity and POP.
- To focus on etiopathogenesis, clinical consequences, and prevention/treatment strategies.
Main Methods:
- Narrative literature review using PubMed, Scopus, and Google Scholar.
- Synthesized studies on obesity, POP, extracellular matrix, genetics, epigenetics, inflammation, and surgical outcomes.
Main Results:
- Visceral adiposity increases intra-abdominal pressure, weakening the pelvic floor.
- Obesity alters extracellular matrix remodeling via collagen metabolism, adipokines, inflammation, and epigenetics.
- Obesity complicates POP management and increases recurrence risk, potentially amplified by genetic factors.
Conclusions:
- Obesity is a key risk factor and therapeutic challenge for POP.
- Understanding obesity-POP interactions (mechanical, molecular, genetic) aids personalized strategies.
- Further research is needed for personalized POP prevention and treatment in obese women.
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