Aggressive large cell neuroendocrine carcinoma of the right colon: a case report

Neuroendocrine carcinomas of the colon are aggressive and rare tumors that often present locally advanced and/or with distant metastases at diagnosis. Their incidence is reported to be <1%. Surgery plays a major role as the initial treatment for locally advanced disease, followed by adjuvant chemotherapy, since most of the cases present in the advanced stage. Despite this, the overall prognosis is reported to be worse, with a median survival of 9 to 14 months. This is a case of an aggressive large cell neuroendocrine carcinoma of the right colon treated with upfront surgery followed by adjuvant chemotherapy.