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Real-World Safety of Intravitreal Complement Inhibitor Avacincaptad Pegol for Geographic Atrophy
Alexander Shaer1, Tadashi Yokoi1,2, Eshani Ragam1
1Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA.
Journal of Vitreoretinal Diseases
|July 28, 2026
Summary
Intravitreal avacincaptad pegol demonstrates a favorable safety profile for geographic atrophy (GA) secondary to age-related macular degeneration (AMD). This real-world study found low rates of adverse events, including inflammation and neovascular AMD conversion.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Background:
- Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a leading cause of irreversible vision loss.
- Intravitreal (IVT) therapies are crucial for managing AMD, but their real-world safety profiles require ongoing evaluation.
- Avacincaptad pegol is an investigational drug targeting GA, necessitating comprehensive safety data.
Purpose of the Study:
- To assess the real-world ocular safety of intravitreal avacincaptad pegol in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD).
- To evaluate the incidence of adverse events, including intraocular inflammation, endophthalmitis, ocular hypertension, and conversion to neovascular AMD (nAMD).
- To provide data for patient counseling and monitoring strategies related to avacincaptad pegol treatment.
Main Methods:
- Retrospective analysis of 845 eyes from 590 patients treated with intravitreal avacincaptad pegol for GA.
- Inclusion of eyes with concurrent neovascular AMD (nAMD) and assessment of conversion (new-onset nAMD) and reactivation rates.
- Evaluation of demographics, treatment characteristics, visual acuity (VA), intraocular pressure (IOP), and adverse events.
Main Results:
- Low rates of intraocular inflammation (0.02%) and endophthalmitis (0.02%) per injection were observed.
- Conversion to nAMD occurred in 3.6% of at-risk eyes (4.3% annualized), with a higher rate in eyes with pre-existing nAMD.
- Visual acuity remained stable (+0.03 logMAR), and persistent ocular hypertension occurred in 1.0% of eyes, with no ischemic optic neuropathy or retinal vasculitis.
Conclusions:
- Avacincaptad pegol exhibits a favorable real-world ocular safety profile for GA secondary to AMD.
- Low incidences of inflammatory events, endophthalmitis, persistent ocular hypertension, and nAMD conversion support its clinical use.
- These findings offer valuable data for guiding clinical practice and patient management.
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