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Interactions between minimal amount of exercise and low-density lipoprotein cholesterol on incident dementia after
Li-Wei Hong1, Hung-Hsuan Chiu2, Pai-Yi Chiu3,4
1Division of Neurosurgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
Abstract:
Cognitive impairment often follows stroke. Regular physical activity has been shown to be associated with reduced dementia risk, while the association with low-density lipoprotein cholesterol (LDL-C) is still not clear. We examined the association of minimal amount of exercise (MAE) and LDL-C with incident dementia after stroke. A retrospective cohort study was conducted using the History-Based Artificial Intelligence Clinical Diagnosis of Dementia Syndrome project, including adults aged 50 years or older with stroke from three medical centers in Taiwan. MAE and LDL-C were used to classify individuals. Among 679 post-stroke individuals without dementia at baseline, exercise was associated with better cognitive and functional status. Dementia progression was highest in the low LDL-C/no exercise group and lowest in the high LDL-C/exercise group. Regular MAE, not too low LDL-C levels (≥100 mg/dL), or both combined, were associated with a lower risk of progression to incident dementia.
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