Related Experiment Video
Updated: Aug 5, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Emerging progress in ruthenium-catalyzed transfer and asymmetric transfer hydrogenation
1Assistant Professor, Dept. of Chemistry, Panchakot Mahavidyalaya P.O. - Neturia, Dist. - Purulia Sarbari 723121 West Bengal India wrahaman@gmail.com.
None:
Ruthenium-catalysed transfer hydrogenation (TH) and asymmetric transfer hydrogenation (ATH) are well recognised as efficient and environmentally benign methods for synthesising chiral alcohols, amines, and key intermediates used in the pharmaceutical and fine chemical industries. In particular, Ru-catalysed ATH combined with dynamic kinetic resolution (DKR) allows for the stereoconvergent synthesis of complex chiral compounds from racemic carbonyl substrates with high efficiency and excellent enantioselectivity. Despite these significant advances, important challenges remain in achieving precise control over both regioselectivity and stereoselectivity of multifunctional chemical systems. Overall, this review summarises advances in TH and ATH from 2020 to 2025, focusing on catalyst design, substrate scope, mechanistic insights, and methodology development to guide the rational design of advanced ruthenium-based catalysts for the efficient synthesis of enantioenriched alcohols and complex molecules.
More Related Videos
10:39Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
Published on: August 23, 2018
12:19Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
Published on: November 29, 2018
Related Concept Videos
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Reduction of Alkenes: Catalytic Hydrogenation
Metals like palladium, platinum, and nickel are commonly used in their solid forms — fine powder on an inert surface. As these catalysts remain insoluble in the reaction mixture, they are referred to as heterogeneous catalysts.
The hydrogenation process takes place on the surface of...
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
Radical Anti-Markovnikov Addition to Alkenes: Overview
Olefin Metathesis Polymerization: Overview
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
Regioselectivity and Stereochemistry of Hydroboration
Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn stereochemistry.