Electrochemically-induced regioselective cyclization of N-methacryloyl hydrazones: efficient synthesis of
Ya'nan Ran1, Miao Yu1, Shengyu Cui1
1College of Pharmacy, Qiqihar Medical University Qiqihar Heilongjiang 161006 People's Republic of China liuleiyaoxue1987@163.com.
Abstract:
An electrochemically driven redox strategy has been developed for the regioselective synthesis of phosphorus-containing 2-pyrazolin-5-ones via radical addition-cyclization cascades. This metal-free protocol enables the efficient incorporation of symmetrical phosphoryl radicals into N-methacryloyl hydrazones under mild conditions. The protocol demonstrates broad substrate scope. Various control experiments explored the merits and the plausible mechanism of the electrochemical phosphorylation systems. This work provides a sustainable and versatile approach to phosphorus-containing heterocycles, holding promise for applications in medicinal chemistry.
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