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Unveiling meropenem-induced thrombocytopenia: Insight from a positive rechallenge case
Mahdi Aleid1, Fatimah Alsaif1, Ahmed Alkudaimi1
1Department of pharmacy, Mouwasat Hospital, Qatif, Saudi Arabia.
Abstract:
Meropenem is a broad-spectrum carbapenem antibiotic widely used to treat serious infections.Although generally safe, it can rarely cause drug-induced thrombocytopenia (DITP), a potentially life-threatening condition. We report a case of a 43-year-old male who developed progressive thrombocytopenia after starting meropenem within 3 days, with platelet count recovering upon drug discontinuation. A positive rechallenge with meropenem led to rapid recurrence of thrombocytopenia, giving a probable association. Platelet count improved after permanent cessation of the drug. This case underscores the need for clinicians to be aware of meropenem-induced thrombocytopenia, emphasizing prompt recognition and discontinuation to prevent complications. Regular platelet monitoring during therapy is advised for early detection.
Insights
Meropenem, a common antibiotic, can rarely cause drug-induced thrombocytopenia (DITP). This case highlights the importance of recognizing and stopping meropenem promptly if DITP occurs, as platelet counts recovered after discontinuation.
Area of Science:
- Pharmacology
- Hematology
- Infectious Diseases
Background:
- Meropenem is a broad-spectrum carbapenem antibiotic.
- Drug-induced thrombocytopenia (DITP) is a rare but serious adverse effect.
- Prompt recognition and management of DITP are crucial.
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