Related Experiment Video
Updated: Aug 5, 2026

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
Published on: February 25, 2022
Lambda restricted light chain as pathogenic cause of POEMS syndrome: a review of the hypothesis
Rebecca Troutman1, Angela Wagner1, Elizabeth Delery1,2,3
1Wood College of Osteopathic Medicine, Marian University, Indianapolis, IN, United States.
Abstract:
POEMS syndrome is a rare and chronic paraneoplastic syndrome characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes. The pathophysiology of this disease is not well understood, but current research focuses on the increase in VEGF and the highly restrictive nature of λ light chains produced by monoclonal plasma cells. Recently, studies have looked deeper into the possibility of these λ light chains being a major factor in onset and progression of this disease focusing on molecular mimicry and links to viral infections. This mini review will summarize current literature on POEMS syndrome as well as hypothesize and analyze the role of the λ light chain in the pathophysiology of the disease.
More Related Videos
Related Concept Videos
Myasthenia Gravis ll: Pathophysiology
Lysosomal Hydrolases
Cardiomyopathy IV: Restrictive Cardiomyopathy
Parkinson Disease ll: Pathophysiology
Atypical Pneumonia
Antiprotozoal Agents

