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Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
Published on: February 3, 2014
Right ventricular longitudinal function is associated with exercise capacity in pre-capillary pulmonary hypertension:
Raluca Jumatate1,2, Ashkan Labaf1, Annika Ingvarsson1
1Department of Clinical Sciences, Lund, Cardiology, and Section for Heart Failure and Valvular Disease, Lund University, Skane University Hospital, Sweden.
European Heart Journal. Imaging Methods and Practice
|July 28, 2026
Summary
Right ventricular longitudinal function in precapillary pulmonary hypertension (PHprecap) is linked to exercise capacity. NT-proBNP offers a moderate view of filling pressures, suggesting stress testing may better assess functional impairment.
Area of Science:
- Cardiology
- Pulmonary Medicine
- Medical Imaging
Background:
- Right ventricular (RV) failure is critical in precapillary pulmonary hypertension (PHprecap) outcomes.
- Current risk assessment uses functional capacity and NT-proBNP, but RV function links remain unclear.
Purpose of the Study:
- To investigate the association between functional capacity, NT-proBNP, and RV function in PHprecap patients.
- To clarify the relationship between RV function parameters and clinical assessments.
Main Methods:
- 49 PHprecap patients underwent 6-minute walk distance (6MWD), NT-proBNP, right heart catheterization, echocardiography, and cardiac MRI.
- Multivariable analysis adjusted for age and sex was performed.
Main Results:
- Impaired RV function (e.g., reduced RVEFCMR, FWSECHO, FACECHO) was observed.
- 6MWD correlated with RV longitudinal function (FWS, TAPSE/sPAP).
- NT-proBNP associated with RV filling pressures (TAPSE/sPAP, S'/sPAP, CMR-FWS).
Conclusions:
- Impaired RV longitudinal function is significantly associated with exercise capacity in PHprecap.
- NT-proBNP moderately reflects right-sided filling pressures.
- Stress-based RV evaluation may be superior to resting assessment for capturing functional impairment.
