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Published on: January 28, 2016
Light-Activated Communication Between Synthetic and Living Cells via Photoresponsive Membranes
Roberto Barbaro1, Paola Albanese1,2,3, Matilde Colella4
1Department of Chemistry, University of Bari Aldo Moro, Bari, Italy.
Chembiochem : a European Journal of Chemical Biology
|July 28, 2026
Summary
Synthetic cells (SCs) can now communicate with human cancer cells using light. This light-responsive platform releases signaling molecules to control cellular functions, paving the way for new biomedical applications.
Area of Science:
- Biotechnology
- Synthetic Biology
- Cellular Engineering
Background:
- Synthetic cells (SCs) are programmable biomimetic systems with controllable functions.
- SCs can respond to external stimuli for cargo release and cell communication.
Purpose of the Study:
- To develop a light-responsive synthetic cell platform.
- To establish chemically mediated communication between SCs and human cancer cells.
Main Methods:
- Engineered light-responsive synthetic cells.
- Stimulation with light to trigger release of signaling molecules (ATP, histamine).
- Monitoring of intracellular calcium signaling in human cancer cells.
Main Results:
- Demonstrated light-induced release of signaling molecules from SCs.
- Showcased activation of calcium signaling pathways in human cancer cells.
- Established chemically mediated communication between synthetic and living cells.
Conclusions:
- Feasibility of remotely controlled communication between synthetic and living cells.
- Potential of SCs as bio-hybrid interfaces for cellular modulation and therapeutic delivery.
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