Guanidine-based drugs in cancer therapy

Area of Science:

• Medicinal Chemistry
• Oncology
• Drug Design

Background:

• Guanidine-containing molecules are nitrogen-rich compounds with unique properties.
• Their ability to form non-covalent interactions and act as superbases makes them valuable in drug development.
• These features underpin a broad range of biomedical applications.

Purpose of the Study:

• To provide a comprehensive review of guanidine-based structures.
• To focus on the application of guanidine scaffolds in oncology.
• To cover approved drugs, clinical trial agents, and preclinical candidates.

Main Methods:

• Literature review of guanidine-containing molecules in cancer research.
• Analysis of clinically approved drugs, agents in clinical trials, and preclinical candidates.
• Integration of fundamental chemistry principles with translational oncology applications.

Main Results:

• Guanidine scaffolds are pivotal in medicinal chemistry and drug design.
• Significant number of guanidine-based compounds show promise in cancer treatment.
• The review covers a spectrum of guanidine structures from approved to preclinical agents.

Conclusions:

• Guanidine-based structures possess significant potential for innovative cancer therapeutic strategies.
• The versatility of guanidine scaffolds continues to drive advancements in oncology.
• Further research integrating chemistry and translational applications will unlock new cancer treatments.