Related Experiment Video
Updated: Aug 5, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Guanidine-based drugs in cancer therapy
Almudena Del Campo-Balguerías1, Alberto Ocaña2, Iván Bravo3
1Universidad de Castilla-La Mancha, Departamento de Química Inorgánica, orgánica y bioquímica, Facultad de Farmacia-Centro de Innovación en Química Avanzada (ORFEO-CINQA), Unidad nanoDrug, 02008 Albacete, Spain.
Abstract:
Guanidine-containing molecules represent a versatile class of nitrogen-rich compounds with unique structural and physicochemical features that underpin a wide spectrum of biomedical applications. Their capacity to engage in non-covalent interactions and function as superbases has established them as pivotal components in medicinal chemistry and drug design. This review provides a comprehensive overview of guanidine-based structures, with a particular focus on oncology, covering clinically approved drugs, agents currently in clinical trials, and emerging candidates in preclinical development. By integrating fundamental chemistry with translational applications, this work underscores the continuing potential of guanidine scaffolds to inspire innovative therapeutic strategies against cancer.
More Related Videos
09:45Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
10:28Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells
Published on: January 10, 2018
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Drugs that Stabilize Microtubules
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Drugs that Destabilize Microtubules
Targeted Cancer Therapies
There are several types of targeted therapies against specific...