Guanidine-based drugs in cancer therapy

Area of Science:

• Medicinal Chemistry
• Oncology
• Drug Design

Background:

• Guanidine-containing molecules are nitrogen-rich compounds with unique properties.
• Their ability to form non-covalent interactions and act as superbases makes them valuable in medicinal chemistry.
• These features are key to their wide range of biomedical applications.

Purpose of the Study:

• To provide a comprehensive review of guanidine-based structures in oncology.
• To cover clinically approved drugs, agents in clinical trials, and preclinical candidates.
• To underscore the therapeutic potential of guanidine scaffolds against cancer.

Main Methods:

• Literature review of guanidine-based compounds.
• Focus on applications in cancer treatment.
• Analysis of approved, trial-stage, and preclinical oncology drugs.

Main Results:

• Guanidine scaffolds are pivotal in medicinal chemistry and drug design.
• Significant number of guanidine-based drugs are approved or in development for cancer.
• Demonstrated versatility in targeting various cancer types.

Conclusions:

• Guanidine structures offer a promising scaffold for developing novel cancer therapeutics.
• Integrating chemistry and translational research highlights their potential.
• Continued exploration of guanidine derivatives is essential for future oncology strategies.