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Updated: Aug 5, 2026

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
Epigenetic memory of inflammation as a driver of cancer risk: insights from Colitis
Alok K Mishra1, Umar Khalid Khan1, Bushra Ateeq2
1Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, UP 208016, India.
Abstract:
Chronic inflammation increases cancer risk, yet the mechanisms linking transient injury to long-term susceptibility remain elusive. Nagaraja et al [1] demonstrate that intestinal stem cells retain durable epigenetic memory of colitis, thereby priming tumorigenesis. This discovery reframes cancer initiation as a consequence of heritable chromatin states, introducing an additional regulatory dimension that operates alongside, and beyond, genetic aberrations. By positioning inflammation induced epigenetic memory as a novel axis for cancer predisposition, this study open avenues for biomarker development and preventive therapeutic strategies.
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