Deep Vein Thrombosis in Hospitalized Patients with COVID-19: Incidence, Distribution, Predictors, and Clinical

Osmar Max Gonçalves Neves1, Guilherme Neves Lima2, Paula Santos Nunes3

  • 1Doctoral Program in Bioscience and Health, University of Tiradentes, Aracaju, Sergipe, Brazil.

Insights

Deep vein thrombosis (DVT) is uncommon in hospitalized COVID-19 patients but linked to severe outcomes. Prior DVT history is the strongest predictor, suggesting targeted screening for high-risk individuals.

Area of Science:

  • Cardiology
  • Pulmonology
  • Infectious Diseases

Background:

  • COVID-19 is associated with an increased risk of venous thromboembolism.
  • Understanding deep vein thrombosis (DVT) in hospitalized COVID-19 patients is crucial for risk stratification and management.

Purpose of the Study:

  • To determine the incidence, anatomical location, and clinical predictors of DVT in COVID-19 patients.
  • To analyze the association between DVT and clinical outcomes in this population.

Main Methods:

  • Retrospective cohort study of 5,831 hospital admissions between 2020 and 2024.
  • Analysis of demographic data, comorbidities, imaging, and clinical outcomes.
  • Multivariable logistic regression to identify independent predictors of DVT.

Main Results:

  • DVT was infrequent but associated with higher rates of ICU admission, mechanical ventilation, prolonged hospitalization, and mortality.
  • Pulmonary embolism was more frequent in patients with DVT.
  • Independent predictors included prior DVT, obesity, smoking, and oxygen requirement.

Conclusions:

  • DVT in hospitalized COVID-19 patients, though uncommon, significantly increases morbidity and mortality.
  • A history of venous thrombosis is the strongest predictor of DVT.
  • Risk-adapted diagnostic strategies, including ultrasound, are needed despite prophylaxis.
Abstract

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