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Updated: Aug 5, 2026
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
tRNAs at the Virus-Host Interface
Deeksha Madhry1, Varsha Meena1, Riya Roy1
1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.
Wiley Interdisciplinary Reviews. RNA
|July 28, 2026
Summary
Viruses manipulate host transfer RNA (tRNA) modifications and functions to aid their replication. Understanding these viral strategies offers new antiviral targets by disrupting viral protein synthesis.
Area of Science:
- Molecular Biology
- Virology
- Biochemistry
Background:
- Transfer RNA (tRNA) is crucial for gene expression, cellular homeostasis, and disease.
- Human tRNAs possess chemical modifications essential for their structure and function.
- Viruses rely on host translation machinery, making tRNA a target for manipulation.
Purpose of the Study:
- To review how viruses exploit tRNA epitranscriptomics.
- To highlight recent advances in tRNA sequencing and profiling.
- To identify novel antiviral targets by understanding viral manipulation of host tRNA.
Main Methods:
- Review of existing literature on tRNA function and viral interactions.
- Analysis of recent tRNA sequencing and profiling techniques.
- Examination of viral strategies to manipulate tRNA structure and function.
Main Results:
- Viruses exploit host tRNA structure and function through various mechanisms.
- Viral manipulation of tRNA epitranscriptomics is a key strategy.
- Advances in tRNA profiling reveal novel insights into host-virus interactions.
Conclusions:
- Understanding viral exploitation of the tRNA landscape is critical for antiviral development.
- Targeting viral manipulation of tRNA offers a promising strategy to inhibit viral replication.
- Novel antiviral therapies can be developed by interfering with viral protein synthesis and replication.
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