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Protecting the brain from post-stroke cognitive impairment and dementia with multimodal exercise training: study
Kevin Moncion1,2, Lynden Rodrigues1,2, Ashanté Bon1,2
1School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
BMJ Open
|July 28, 2026
Summary
This study investigates if multimodal exercise in early stroke recovery improves cognition and reduces dementia risk. Results will inform future neuroprotective strategies for stroke survivors.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Clinical Trials
Background:
- Stroke survivors face high risks of cognitive impairment and dementia.
- The subacute phase post-stroke is a critical window for neuroprotection.
- Effectiveness of early multimodal exercise on cognitive decline and dementia risk is unknown.
Purpose of the Study:
- To evaluate the impact of 12-week multimodal exercise on cognition in subacute stroke.
- To assess neuroimaging markers and blood biomarkers related to dementia risk.
- To compare moderate-to-high-intensity exercise against a low-intensity comparator.
Main Methods:
- Phase 3, assessor-blinded, adaptive randomized controlled trial (NCT07445841).
- 12-week multimodal exercise vs. low-intensity comparator.
- Primary outcome: cognition (ADAS-Cog-13); secondary: neuroimaging, biomarkers.
Main Results:
- This section is to be filled once the study is completed and results are available.
Conclusions:
- This section is to be filled once the study is completed and results are available.