Related Experiment Video

Updated: Aug 5, 2026

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs
05:40

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Published on: December 22, 2023

Fetal Gastroschisis

Sami Backley1, Allison Speer, Anthony Johnson

  • 1Division of Fetal Intervention, Department of Obstetrics, Gynecology and Reproductive Sciences, and the Department of Pediatric Surgery, McGovern Medical School at UTHealth Houston, Houston, Texas.

Obstetrics and Gynecology
|July 28, 2026
PubMed

Insights

Gastroschisis is a congenital abdominal wall defect involving visceral herniation. Current evidence suggests a model involving embryonic disruption, vascular issues, and environmental factors leading to this condition.

Area of Science:

  • Developmental Biology
  • Pediatric Surgery
  • Medical Genetics

Background:

  • Gastroschisis is a common congenital abdominal wall defect.
  • It involves herniation of abdominal viscera through a paraumbilical defect.
  • The exact cause involves a complex interplay of factors.

Purpose of the Study:

  • To provide an overview of gastroschisis.
  • To cover embryology, pathophysiology, and diagnosis.
  • To discuss management and potential fetal interventions.

Main Methods:

  • Review of current evidence and established models.
  • Synthesis of information on embryogenesis and pathology.
  • Compilation of clinical management strategies.

Main Results:

  • Gastroschisis results from early embryonic morphogenetic disruption.
  • Vascular compromise and environmental influences exacerbate the defect.
  • A model involving defective body wall formation and vascular factors is supported.

Conclusions:

  • Gastroschisis pathogenesis is multifactorial.
  • Understanding embryology and pathophysiology is key to management.
  • This series offers a comprehensive guide to gastroschisis care.

More Related Videos

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse08:19

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Hiatal Hernia01:25

Hiatal Hernia

A hiatal hernia is the abnormal protrusion of the stomach or other abdominal organs through the esophageal hiatus of the diaphragm into the thoracic cavity.Normally, the gastroesophageal junction (GEJ) lies below the diaphragm and is supported by the phrenoesophageal membrane, the diaphragmatic crura, and connective tissues. Weakening of these structures—due to aging, congenital defects like a short esophagus, or increased intra-abdominal pressure from coughing, obesity, pregnancy, or heavy...
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...