Related Experiment Video
Updated: Aug 5, 2026
05:28
Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
Regulated cell death-induced coagulation dysfunction in sepsis
Min Li1,2,3, Ao Li1,2,3, Sipin Tan4,5,6
1Department of Pathophysiology, Xiangya School of Basic Medicine Science, Central South University, No.110, Xiangya Road, Changsha, 410078, PR China.
Journal of Thrombosis and Thrombolysis
|July 28, 2026
Summary
Regulated cell death (RCD) pathways significantly contribute to sepsis-induced coagulopathy (SIC). Understanding RCD mechanisms offers new avenues for diagnosing and treating this life-threatening condition.
Area of Science:
- Immunology
- Pathophysiology
- Molecular Biology
Background:
- Sepsis-induced coagulopathy (SIC) is a severe complication of sepsis, associated with high mortality.
- Regulated cell death (RCD) pathways are increasingly recognized as key upstream mediators in SIC pathogenesis.
Purpose of the Study:
- To review the role of RCD in SIC, integrating various cell death pathways.
- To explore RCD-derived Damage-Associated Molecular Patterns (DAMPs) in coagulation dysfunction.
- To outline RCD-guided strategies for patient stratification and targeted therapies.
Main Methods:
- Comprehensive literature review of RCD pathways (pyroptosis, NETosis, ferroptosis, necroptosis, PANoptosis) in SIC.
- Analysis of RCD-derived DAMPs and their impact on coagulation.
- Evaluation of biomarkers for patient stratification and combination therapies.
Main Results:
- RCD pathways critically influence coagulation dysfunction in sepsis.
- RCD-derived DAMPs serve as potential mediators and biomarkers.
- Phenotype-directed therapies targeting RCD show promise for SIC management.
Conclusions:
- RCD-guided phenotyping offers a framework for understanding and managing SIC.
- Precision immunomodulation based on RCD holds transformative potential for clinical practice.
- Bridging cell death and thrombosis research is crucial for advancing SIC treatment.
More Related Videos
Related Concept Videos
01:25Acute Inflammation III: Local and Systemic Effects
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
01:30Overview of Cell Death
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
01:16Necrosis
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
01:16Cellular Injury IV: Necrosis
Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
01:11Cellular Injury IlI: Cellular Death
Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...
01:00Cellular Injury I: Introduction
Cellular injury occurs when a cell cannot maintain homeostasis or adapt to stressors such as hypoxia, toxins, or trauma. Depending on severity and duration, injury may be reversible, allowing recovery, or irreversible, leading to cell death.General Mechanisms of Cell InjuryAlthough causes vary, most cellular injuries arise from a few key mechanisms that disrupt essential functions and often amplify one another. Cell survival depends on the extent and balance of these disturbances.ATP depletion...