Regulated cell death-induced coagulation dysfunction in sepsis
Related Experiment Video
Updated: Aug 5, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
Min Li1,2,3, Ao Li1,2,3, Sipin Tan4,5,6
1Department of Pathophysiology, Xiangya School of Basic Medicine Science, Central South University, No.110, Xiangya Road, Changsha, 410078, PR China.
Abstract:
Regulated cell death (RCD) has emerged as a pivotal upstream mediator supported by correlative preclinical and clinical evidence in the pathogenesis of sepsis-induced coagulopathy (SIC), a life-threatening complication strongly linked to increased mortality. RCD-guided phenotyping integrates pyroptosis, NETosis, ferroptosis, necroptosis, and PANoptosis pathways to systematically redefine SIC - from molecular signatures to targeted interventions. This review comprehensively examines how RCD-derived Damage-Associated Molecular Patterns (DAMPs) mediate coagulation dysfunction, explores subtype-specific biomarkers for patient stratification, and outlines phenotype-directed combination therapies. We further investigate unresolved challenges and future developments in RCD-guided precision immunomodulation, emphasizing the transformative potential of RCD-based frameworks to advance the clinical management of SIC by bridging insights from cell death and thrombosis research.
More Related Videos
Related Concept Videos
Acute Inflammation III: Local and Systemic Effects
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Cellular Injury IV: Necrosis
Cellular Injury IlI: Cellular Death
Cellular Injury I: Introduction
