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Updated: Aug 5, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
Clinical justification for osteoporosis investigation: transitioning from opportunistic to diagnostic referrals from
Robert Meertens1, Claire Senior1
1Department of Health and Care Professions, University of Exeter, Exeter, United Kingdom.
Abstract:
Clinical justification remains fundamental to the safe use of imaging involving ionising radiation, requiring a favourable balance between diagnostic benefit and stochastic risk. Concurrently, advances in imaging technology and artificial intelligence have enabled opportunistic identification of additional pathologies beyond the primary indication for imaging. This opinion article discusses how emerging opportunistic osteoporosis detection technologies may eventually transition into clinically justified diagnostic pathways in their own right.
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